gestational weight gain/hypoxia

Metabolic impairments in maternal obesity and gestational diabetes mellitus (GDM) induce an abnormal environment in peripheral blood and cause vascular structure alterations which affect the placental development and function. A GDM model was developed using C57BL/6J female mice fed with high fat

OBJECTIVE To quantitatively define the coronary vascular bed in the 21-day-old rat fetus with gestational normoxia and hypoxia; to determine if maternal supplemental oxygen and/or oxygen-carrying perfluorocarbons (PFCs) influence development of coronary vessels; and to compare the results using

Pregnancies that occur at high altitude are bedevilled by many complications and particularly those due to pressure disorders. Although there are many maternal and placental mechanisms that are brought to bear to "blunt" the effects of hypoxia in the fetus, these pregnancies are characterised by low

The dual stresses of pregnancy and exercise may create conflicting physiological demands that could adversely affect pregnancy outcome. Specifically, redistribution of uterine blood flow and subsequent fetal hypoxia, hyperthermia and the risk of teratogenic effects, decreased carbohydrate

BACKGROUND Uteroplacental hypoxia has been reported to lower estrogen levels in preeclampsia as the result of reduced aromatase activity. OBJECTIVE We asked whether the chronic hypoxia of residence at high altitude in the absence of preeclampsia lowered estrogen, whether such effects differed in

OBJECTIVE To assess 11-β-hydroxysteroid dehydrogenase 2 (11β-HSD2) gene expression patterns in human placental samples from intrauterine growth restriction (IUGR) pregnancies using normal pregnancy as control. METHODS We compared 11-β-HSD2 gene expression in placental samples from all IUGR