hyperaldosteronism/potassium

BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to a process for reversing or preventing secondary aldosteronism and potassium depletion induced by diuretic therapy and to compositions useful for this purpose. 2. Description of the Prior Art Most clinically useful oral

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to steroid derivatives having aldosterone-antagonistic activity more potent than that of spironolactone. 2. Description of the Prior Art The aldosterone antagonists have widely been used alone in diagnosis and

The invention relates to novel steroid compounds having the basic structure of 20-spiroxane, namely lactones of the 7.alpha.-acylthio-9.alpha.,11.alpha.-epoxy-20-spirox-4-ene-3,21-dione type of the formula I ##STR2## in which R represents lower alkanoyl and --A--A-- represents an ethylene or