hypercalcemia/phosphatase

Background The investigators have previously completed a clinical trial with long-term vitamin D3 supplementation in healthy humans during a season with negligible UVB in terms of serum 25-hydroxy vitamin D (25(OH)D) increase. In this study (submitted, unpublished), a temporary increase was

Introduction: hCG signals through the LHCGR receptor and is know to stimulate testosterone production. hCG stimulation tests are therefore used to evaulate the capacity of the testis to respond to LH/hCG and thereby determine the degree og gonadal insufficiency and need for testosterone

Hypophosphatasia (HPP) is a rare genetic disorder characterized the abnormal development of bones and teeth. These abnormalities occur due to defective mineralization, the process by which bones and teeth take up minerals such as calcium and phosphorus. These minerals are required for proper

Design & Methodology: 1. Nature of the study: It is ( prospective cohort study). 2. Study subjects: *Target Population: Patients, fulfilling the inclusion criteria for the research, will be selected from Assiut clinical oncology department in Assiut University Hospitals. - Sample size: 20

Introduction: Vitamin D is a versatile signaling molecule with a well-established role in the regulation of calcium homeostasis and bone health. The spectrum of vitamin D target-organs has expanded and it has been suggested that vitamin D influences the immune system, endocrine organs such as

PRIMARY OBJECTIVES: I. Demonstrate that carbon-11 acetate (11C-acetate) and 18F-fluoride (fluorine F 18 sodium fluoride) PET scans change as a result of treatment for men with metastatic castration-resistant prostate cancer by comparison of pre-treatment and 6-12 week post-treatment images

Study background and rationale Receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) play key roles in regulating bone turnover. They are involved in the mechanism of "crosstalk" between osteoblasts and osteoclasts. After binding with RANK,

The scientific purpose of this study is to obtain data on the use of sVDRA(Selective Vitamin D Receptor Activator) in real-life clinical practice. This study will allow us to observe drug effectiveness in a distinct geography. Treatment effects, as well as maintenance of the results will be recorded

Bone is the most common site of distant breast cancer recurrence, and 65-75% of women with advanced breast cancer will develop bone metastases during the course of their disease. Bone metastases can significantly adversely impact on quality of life by causing pain and skeletal related events (SREs)

Volunteers will be recruited from amongst the preventive health check subjects, neighboring offices, hospital employees and corporate associates of SBISR after obtaining a detailed informed consent. The study will include 300 subjects with the following selection criteria. INCLUSION CRITERIA 1. 35

A.1.a. Introduction This is a prospective, randomized, double-blind clinical trial designed to evaluate the effect of 24 months of supplementation with vitamin D3 and calcium on bone mass accrual in HIV-infected children and adolescents. A.1.b. Subject recruitment i. HIV-infected subjects on will be

Vitamin D is an essential nutrient that plays an important role in calcium metabolism and bone health. In recent years, biomarkers like PTH, calcium absorption have been used to define relevant biological indices of vitamin D nutritional status. Prevalence of 25(OH)D in Asian Indians Several studies

Secondary hyperparathyroidism is a common feature in patients with chronic kidney disease. Its clinical consequences include renal osteodystrophy, calciphylaxia and potentially vascular calcifications with increased morbidity and mortality. Reduced synthesis of active vitamin D contributes to

Vitamin D status is currently judged by serum 25(OH)D and the parathyroid hormone (PTH)-25(OH)D dynamic (1). The ultimate effect of vitamin D on human health is a healthy skeleton, which is characterized in infancy by normal linear growth and bone mineral accretion and absence of bone related