indospicine/necrosis

BACKGROUND Four dogs presented with clinical signs of severe hepatic disease after consuming a commercial camel meat diet. METHODS Laboratory investigation revealed evidence of severe liver disease, including markedly increased serum alanine aminotransferase (ALT) activity and total bilirubin

An outbreak of liver disease which killed more than 30 dogs at Alice Springs was associated with feeding meat from horses, some of which had developed Indigofera linnaei poisoning (Birdsville horse disease). Affected livers were small, nodular and yellow. There was associated jaundice, ascites,

The non-protein amino acid indospicine, which occurs in the free state in high concentration in the tropical pasture legume Indigofera spicata, causes toxic liver lesions in ruminants. Indospicine is a specific antagonist of arginine and an inhibitor of protein synthesis. The liver lesion was

Three ponies continuously grazed a pasture containing an estimated 24% Indigofera spicata (wet weight basis) for 4-6 weeks in April and May 2004. They developed ataxia, paresis, depression, muscle fasciculations, dysphagia, ptyalism and halitosis. Two also developed corneal opacity. One pony