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The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox.

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The molecular basis of "metabolically healthy obese" and "metabolically unhealthy non-obese" phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese

Nitric oxide-dependent downregulation of adipocyte UCP-2 expression by tumor necrosis factor-alpha.

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Uncoupling protein-2 (UCP-2) is a mitochondrial protein expressed in adipocytes and has recently been involved in the control of energy dissipation. Because obesity is characterized by an imbalance between energy intake and expenditure and by an enhanced adipocyte-derived secretion of tumor necrosis

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