Manuka Honey will be placed in the sockets of the extracted third molars in this group

No any special material will be placed in the sockets of the extracted third molars in this group

Surgical Extraction of Impacted Third Molars

This material is going to be placed into the sockets of the extracted third molars in the experimental group

Manuka Honey

Department of Oral and Maxillofacial Surgery, University of Damascus Dental School

The Use of Manuka Honey to Improve Healing After Third Molars Surgery

The Effect of Topical Application of Manuka Honey on Healing After Extraction of Impacted Lower Third Molars: A Split-Mouth Design Randomized Controlled Trial

Postoperative Symptom Severity (PoSSe) Scale will be used for this variable. The patient will be asked to fill in a questionnaire on the 7th day following surgery. This questionnaire is used to assess postoperative discomfort in patients who have third molars extracted. PoSSe Scale consists of 7 sub-scales that investigate the patient's ability to enjoy food; speak properly; perceive altered sensations, appearance, pain, and sickness; and interference with daily activities.

In order to assess facial swelling, the distances between the labial commissure and the tragus, and between the lateral canthus and the gonion will be measured.
The change between 3 days and before surgery will give an idea about the amount of swelling that occurred following surgery.
Between 3 days and 7 days will give an idea about the change that occurred in this period.

Mouth opening range will be assessed by measuring the distance between the upper and lower incisors using a vernier caliper when the patient is asked to open his/her mouth as much as possible.
The presence of limited opening of the mouth is an indication of trismus.

using a Visual Analog Scale of Faces (VASoF).

The presence of a dry socket condition will be checked out at two time points.

This will be assessed using Cone-beam computed tomography (CBCT) images. Hounsfield Units will be used to quantify bone density and quality.

This will be assessed using panoramic radiographs

Damascus University

Irradiated organic manuka honey 5ml 4 times a day held in mouth for 30 secs then swallowed

Sugar-free placebo gel 5ml 4 times a day, swished and held in mouth for 30 secs then swallowed

Irradiated organic manuka honey 5ml 4 times a day held in mouth for 30 secs then swallowed
manuka honey: Irradiated organic manuka honey 5ml 4 times a day held in mouth for 30 secs then swallowed. May be diluted with equal or twice the volume of water to reduce nausea in patients already nauseated from chemotherapy.

Honey

Sugar-free placebo gel 5ml 4 times a day, swished and held in mouth for 30 secs then swallowed
placebo gel: Sugar-free honey-flavoured gel 5ml 4 times a day swished and held in mouth for 30 secs then swallowed. May be diluted with equal or twice the volume of water to reduce nausea in patients already nauseated from chemotherapy.

Placebo

Total

Sex: Female, Male

Race and Ethnicity Not Collected

Weight

Diabetic

Smoker

ECOG > 0

Chemotherapy

Gy = Gray; the international system unit of radiation dose

Radiation Therapy => 7,000 Gy

Worst Radiation Therapy Oncology Group (RTOG) score greater than or equal to Grade 3 mucositis The scale ranges from Grade 0 (No mucositis) to Grade 4 (Necrosis or deep ulceration ± bleeding) where Grade 0 is the best outcome and Grade 4 is the worst outcome.

Severity of Mucositis According to the Radiation Therapy Oncology Group (RTOG) for Patients Who Had at Least One Mucositis Assessment

Severity of Mucositis According to the Radiation Therapy Oncology Group (RTOG) for Patients Who Had a Minimum of 2 Mucositis Assessments

Overall Study

Dr. Philippa Hawley

Radiotherapy Induced Mucositis

Head and Neck Cancer

Irradiated organic manuka honey 5ml 4 times a day held in mouth for 30 secs then swallowed. May be diluted with equal or twice the volume of water to reduce nausea in patients already nauseated from chemotherapy.

manuka honey

Sugar-free honey-flavoured gel 5ml 4 times a day swished and held in mouth for 30 secs then swallowed. May be diluted with equal or twice the volume of water to reduce nausea in patients already nauseated from chemotherapy.

placebo gel

BC Cancer Agency

A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer

British Columbia Cancer Agency

The study was blinded to all except necessary pharmacy staff until after the study was closed.

leptospermum lanigerum/dental caries

The Use of Manuka Honey to Improve Healing After Third Molars Surgery

A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer

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