lichen sclerosus et atrophicus/protease

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Isolation and partial characterization of an elastase-type protease in human vulva fibroblasts: its possible involvement in vulvar elastic tissue destruction of patients with lichen sclerosus et atrophicus.

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登陸註冊

A complete disappearance of orcein positive material was observed in the superficial dermis of patients suffering from Lichen sclerosus et atrophicus. An elastase-type protease was isolated and partially purified from Triton X-100 extracts of human vulvar fibroblasts by gel permeation

Do plasminogen activators play a role in lichen sclerosus?

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登陸註冊

The histological changes of lichen sclerosus suggest that significant remodelling of the extracellular matrix is occurring. As the proteases of the plasminogen activator system have been implicated in tissue remodelling, cell migration and tumour invasion, we performed an immunohistochemical study

Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma.

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登陸註冊

The two main etiological factors for vulvar squamous cell carcinoma (vSCC) are the vulvar dermatosis lichen sclerosus (LS) and high-risk human papillomavirus (hrHPV). Serpin A1 (α1-antitrypsin) is a serine protease inhibitor, which plays a role in the tumorigenesis of various cancer

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