lordosis/sesamum indicum

OBJECTIVE Estrogens are important effectors of reproduction and are critical for upregulating female reproductive behavior or lordosis in females. In addition to the importance of transcriptional regulation of genes by 17β-estradiol-bound estrogen receptors (ER), extranuclear signal transduction

Gonadectomized rats bearing s.c. Silastic capsules containing crystalline oestradiol-17 beta diluted with cholesterol, or oestradiol-17 beta dissolved in sesame oil were tested for the presence of a diurnal rhythm in the display of lordotic behaviour. In experiment 1, female rats received four

Sex differences in the neurobehavioral effects of chronic cannabinoid exposure suggest that gonadal hormones may modify cannabinoid activity. The current experiment assessed the impact of combined cannabinoid and estradiol treatment in ovariectomized, adolescent female rats on subsequent adult

Estrogen has well known effects on sexual behavior, however the role of the estrogen receptors (ER) alpha and beta on sexual behavior remains to be fully determined. This study investigated the individual and co-operative involvement of ERalpha and beta on sexual behaviors in the adult female rat.

Correct perinatal oestrogen levels are critical for sexual differentiation. For example, perinatal exposure to oestrogen causes masculinization and defeminization of the brain in female rats and also induces delayed effects after maturation characterized by early onset of abnormal oestrus cycling.

Progesterone (P) facilitates male-like sexual behavior in female hamsters primed with estrogen. Since estrogen plus P activates lordosis in female hamsters and the site of the hormonal action is at the ventromedial hypothalamus (VMH), it is possible that the same hormones act at the same site to

Recently, we reported that bisphenol A (BPA), an endocrine disrupter, increased progesterone receptor (PR) mRNA in the preoptic area (POA) in adult ovariectomized rats. In the present study, we examined whether BPA also induced expression of PR proteins in both the POA and the ventromedial

An acute injection of estradiol benzoate (EB) to the ovariectomized (OVX) rat activates low levels of lordosis, and subsequent progesterone (P) administration augments lordosis and recruits a complete pattern of sexual behavior including appetitive behaviors (e.g., hops/darts and solicitations).

Progesterone (P) to the ventromedial hypothalamus (VMH) and the ventral tegmental area (VTA) of ovariectomized (OVX), estradiol benzoate (EB)-primed rats and hamsters produces female sexual behavior similar to that seen in proestrous, receptive rodents. Because P's 5alpha-reduced metabolites can

Pregnane neurosteroids may initiate sexual receptivity not only via actions at intracellular receptors, but by affecting gamma-aminobutyric acid (GABA) receptor complexes (GBRs). To investigate whether GBR-mediated actions of an androgenic neurosteroid 5 alpha-androstane-3 alpha, 17 beta-diol (3

Developmental exposure to environmental chemicals with estrogen-like activity is suspected to permanently impair women's health. In this study, a mouse model was used to evaluate whether tris(2,6-dimethylphenyl) phosphate (TDMPP), a chemical with a putative estrogen-like action, impairs sexual

It is hypothesized that systemic α₁-noradrenergic antagonists may interfere with the transmission of sensory stimulation, particularly vaginal--cervical stimulation (VCS), which is crucial for reproductive functioning. To determine if α₁-noradrenergic transmission receptor activity is necessary for

RU 38486 (RU 486, mifepristone) is a potent progesterone receptor antagonist that has been used in humans in the pharmacologic induction of abortion. The effects of exposure to RU 486 during the neonatal period of the rat has not been previously reported. We examined the consequences of such

Male rats rarely show lordosis, a female sexual behavior, because of strong inhibition of the behavior in the lateral septum. Because neonatal treatment with estradiol (E2) in female rats decreases lordosis, it is believed that the lateral septum is a target of E2 action to defeminize or masculinize