nevus/glutathione

A role of SH-compounds such as cysteine and glutathione in melanogenesis in dermal melanocytes cultured from Ota's nevus tissue was demonstrated in relation to another substrate, dihydroxyphenylalanine (DOPA). Chemical analysis of eumelanin and pheomelanin was performed in addition to the

Variations in the melanocortin-1 receptor (MC1R) and in the glutathione-S transferase genes mu1 (GSTM1) and theta 1 (GSTT1) have been reported to influence UV sensitivity and melanoma risk. MC1R is one of the major genes that determine skin pigmentation because the melanocortin-1 receptor regulates

Melanin synthesis is an oxygen-dependent process that acts as a potential source of reactive oxygen species (ROS) inside pigment-forming cells. The synthesis of the lighter variant of melanin, pheomelanin, consumes cysteine and this may limit the capacity of the cellular antioxidative defense. We

Biosynthesis of pigment melanin in pigment cells (melanocytes, nevus cells, melanoma cells) constitutes a distinctive but integrated part of intracellular metabolism. Although the melanin formation takes place in specialized compartments (melanosomes), these structures are not fully "leak-proof"

OBJECTIVE Induction of oxidative stress has been implicated in UV-induced melanoma. We sought to determine whether the antioxidant N-acetylcysteine (NAC) could be safely administered to protect melanocytic nevi from the oxidative stress resulting from acute UV exposure. METHODS Patients at increased