pilocarpine/dichloromethane

OBJECTIVE To develop an RP-HPLC method for assay of pilocarpine in rabbit ocular aqueous humor. METHODS The RP-HPLC method was performed on a column of ODS-C(18) with the mobile phase consisting of 0.5% of triethylamine (TEA) of phosphate solutions (10 mmol/L, pH 2.5) and acetonitrile (98/2,v/v).

OBJECTIVE To compare the pharmacokinetics of 0.5% pilocarpine containing sodium hyaluronate with 1% generic pilocarpine solution. METHODS One hundred albino rabbits were divided into 20 groups, each consisting of 5 animals. Ten groups received 0.5% pilocarpine containing sodium hyaluronate and 10

OBJECTIVE To compare the pharmacokinetics of pilocarpine micron emulsion with generic pilocarpine solution in the aqueous humor. METHODS 60 albino rabbits were used and were divided into 20 groups, each consisting of 3 animals. 10 groups received 2% generic pilocarpine 50 microl as controls; 10