salicylate/dental caries

The salicylate 1,2-dioxygenase (SDO) from the bacterium Pseudaminobacter salicylatoxidans BN12 is a versatile gentisate 1,2-dioxygenase (GDO) that converts both gentisate (2,5-dihydroxybenzoate) and various monohydroxylated substrates. Several variants of this enzyme were rationally designed based

The strong coupling of an IR-active molecular transition with an optical mode of the cavity results in vibrational polaritons, which opens a new way to control chemical reactivity via confined electromagnetic fields of the cavity. In this study, we design a voltage-tunable open microcavity and we

The crystallographic structures of the adducts of salicylate 1,2-dioxygenase (SDO) with substrates salicylate, gentisate and 1-hydroxy-2-naphthoate, obtained under anaerobic conditions, have been solved and analyzed. This ring fission dioxygenase from the naphthalenesulfonate-degrading bacterium

Key amino acid residues of the salicylate 1,2-dioxygenase (SDO), an iron (II) class III ring cleaving dioxygenase from Pseudaminobacter salicylatoxidans BN12, were selected, based on amino acid sequence alignments and structural analysis of the enzyme, and modified by site-directed mutagenesis to

OBJECTIVE To investigate the facilitative role of iontophoresis in drug delivery through intact and caries-affected dentine into the pulp. METHODS Forty-eight intact dentine or caries-affected dentine discs were prepared from freshly extracted human third molars. The hydraulic conductance was

We report the inadvertent administration of activated charcoal in water into the right lung and pleural cavity of a 51-year-old man being treated for a salicylate overdose. A mild chemical pneumonitis developed, as did a sterile empyema. Charcoal-stained fluid drained through a thoracostomy tube for

Cavity-enhanced spectroscopy is a sensitive optical absorption technique but one where the practical applications have been limited to studying small wavelength ranges. This Letter shows that wideband operation can be achieved by combining techniques usually reserved for the communications community

A highly selective optical sensor for chloride, based on the multidentate Lewis acid ionophore [9]mercuracarborand-3, is described herein. This sensor is constructed by embedding the mercuracarborand ionophore, a suitable pH-sensitive lipophilic dye, and lipophilic cationic sites in a plasticized

Choline salicylate (CS) as a derivative of acetylsalicylic acid is commonly used in different drug forms. In medicine, it is applied topically to inflammation of the oral cavity mucosa and in laryngology. However, this substance in the form of an ionic liquid has not been investigated enough. There

OBJECTIVE To evaluate the efficacy of a fluoride dentifrice containing a fixed combination of essential oils (Thymol, Menthol, Eucalyptol, and Methyl Salicylate) in preventing caries in Sprague Dawley rats. METHODS The dentifrice contains 0.76% sodium monofluorophosphate (SMFP) as the fluoride

The possible excretion of acetylsalicylic acid and salicylic acid into human whole-mouth saliva was studied after the ingestion of 1.0 g of acetylsalicylic acid in gelatine capsules. In addition, the oral clearance of both salicylates was determined after a sham intake of acetylsalicylic acid in

BACKGROUND Poison Control Centers follow the acetylsalicylic acid (ASA) treatment guideline to manage unintentional ingestions of topical methyl salicylate liniments. For example, one teaspoon of 30% methyl salicylate cream such as Ben Gay provides an "ASA equivalent dose" of 180 mg/kg for a 10 kg

The degree of association of sodium salicylate and indomethacin with inflammatory cells was measured under in vivo conditions in ascites bearing mice. These animals had sufficient volume of inflammatory effusion in the peritoneal cavity which enabled measurement of drug concentrations

Antimicrobial packaging systems are recognized as effective approaches to prolong food shelf life. In this context, Bio-based PA11 loaded with a food-grade zeolite were prepared using ball milling technology in the dry state. Zeolite was filled with sodium salicylate, as an antimicrobial agent, and

Photonic crystal nanobeam cavities with high-quality factors are very sensitive to the changes of the dielectric properties of their surroundings. Utilizing this high sensitivity and by applying chemical functionalization, an ultrasensitive chemical sensor for gases based on a nanobeam cavity was