simaba/抗癌藥

Fractionation of an aqueous ethanol extract of the wood of Simaba multiflora afforded a new antineoplastic quassinoid, 6 alpha-senecioyloxychaparrin (5), and two known quassinoids 6 alpha-senecioyloxychaparrinone (1) and chaparrinone (2). The structure of 5, which displayed activity against the KB

Fractionation of Simaba multiflora A. Juss. guided by bioassay has resulted in the isolation of a new antileukemic quassinoid 6alpha-senecioyloxychaparrinone (2) and the previously reported quassinoid chaparrinone (3). The structure of the former has been established by spectral and chemical

An antileukemic quassinoid simalikalactone D ( 17) and two anticancer phenolic compounds, emodin and tricin, were isolated from the wood of SIMABA MULTIFLORA (Simaroubaceae) as well as 8-hydroxycanthin-6-one ( 18) and coumarin. The constituents of the genus SIMABA are reviewed.

The South American Simaba cuspidata Spruce and North Indian Ailanthus grandis Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6 alpha-tigloyloxychaparrinone (4a) and the new quassinoid 6

Two new cytotoxic canthin-6-ones, 10-methoxycanthin-6-one (1) and 10-hydroxycanthin-6-one (2) were isolated from the wood of Simaba multiflora (Simaroubaceae). Three canthin-2,6-dione (3), 3-methoxycanthin-2,6-dione (4) and canthin-2,6-dione (5), as well as scopoletin (7) and the novel

Cleomiscosin A (1) has been isolated from Simaba multiflora and Soulamea soulameoides in the Simaroubaceae through bioactivity-directed fractionation and from Matayba arborescens in the Sapindaceae . The structure of cleomiscosin A (1) was established through spectroscopic studies and chemical