All non-ICU medicine and surgery patients at Sinai Health System who have a mid-stream urine culture ordered

Asymptomatic Bacteriuria

Urinary Tract Infections

microbiology lab will not process culture unless called

not processing urine cultures

Mount Sinai Hospital

Safety and Effectiveness of a Laboratory Intervention to Effectively NOT Treat Asymptomatic Bacteriuria

Safety and Effectiveness of a Laboratory Intervention to Effectively NOT Treat Asymptomatic Bacteriuria (SALIENT-A)

serious adverse events associated with not processing urine culture

Rate of serious adverse events in patients without symptoms who did and did not have urine specimens processed

Rate of serious adverse events due to antibiotic therapy in patients who received antibiotics for asymptomatic bacteriuria

Proportion of patients with symptomatic urinary tract infection (UTI) who did not respond to initial empiric antibiotics

individual patient data will not be available to other researchers. This is a quality improvement study

Allison McGeer

Medical Director, Infection Prevention and Control

Mount Sinai Hospital, Canada

Metronidazole added to background TB treatment regimen during initial 2 months

Placebo added to background TB treatment regimen during initial 2 months

Subjects were randomized to receive metronidazole 500 mg TID or placebo for 8 weeks, in addition to an individualized background TB treatment regimen. Total duration of treatment was about 18 months following sputum culture conversion.

Metronidazole

Placebo

Total

Sex: Female, Male

Lesions were defined as nodules (<2 mm, 2-<4 mm, and 4-10 mm), consolidations, collapse, cavities, fibrosis, bronchial thickening, tree-in-bud opacities, and ground glass opacities. Each CT was divided into six zones (upper, middle, and lower zones of the right and left lungs) and independently scored for the above lesions by three separate radiologists blinded to treatment arm. A fourth radiologist adjudicated any scores that were widely discrepant among the initial three radiologists. The HRCT score was determined by visually estimating the extent of the above lesions in each lung zone as follows: 0=0% involvement; 1= 1-25% involvement; 2=26-50% involvement; 3=51-75% involvement; and 4=76-100% involvement. A composite score for each lesion was calculated by adding the score for each specific abnormality in the 6 lung zones and dividing by 6, with the change in composite score measured at 2 and 6 months compared to baseline. Composite sums of all 10 composite scores are reported.

Subjects were randomized to receive metronidazole 500 mg three times daily or placebo for 8 weeks, in addition to an individualized background TB treatment regimen. Total duration of treatment was about 18 months following sputum culture conversion.

Changes in TB Lesion Sizes Using High Resolution Computed Tomography (HRCT).

Time to Sputum Culture Conversion to Negative on Solid Medium

Overall Study

Ray Chen

Tuberculosis

Multi-Drug Resistant Tuberculosis

Blood Draw

CT Scan

PET Scan

National Masan Tuberculosis Hospital

Yonsei University College of Medicine

Metronidazole for Pulmonary Tuberculosis (South Korea)

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Metronidazole Combined With Antituberculous Chemotherapy vs. Antituberculous Chemotherapy With Placebo in Subjects With Multi-Drug Resistant Pulmonary Tuberculosis

vaginitis/vomiting

Safety and Effectiveness of a Laboratory Intervention to Effectively NOT Treat Asymptomatic Bacteriuria

Metronidazole for Pulmonary Tuberculosis (South Korea)

Plasma and Abscess Fluid Pharmacokinetics of Cefpirome and Moxifloxacin After Single and Multiple Dose Administration

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