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Severe lymphocytic adenohypophysitis with selective disappearance of prolactin cells: a histologic, ultrastructural and immunoelectron microscopic study.

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We report the first documented example (case 1) of lymphocytic adenohypophysitis (LAH) associated with selective destruction of prolactin cells. The morphologic data are compared to those obtained in another, more typical case (case 2). Case 1 was a 35-year-old woman with remote history of pregnancy

Silent pituitary plurihormonal adenoma: clinical relevance of immunohistochemical analysis

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Non-functional pituitary adenomas (NFPAs) present low growth rates; however, some are aggressive and invasive. In 2017 the World Health Organization recognized clinically aggressive adenomas as “high-risk pituitary adenomas”. These include the sparsely granulated somatotroph adenoma,

[Primary empty sella syndrome. Clinical and radiological study, and evaluation of pituitary function].

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Empty sella syndrome is an anatomoclinical condition in which the herniation of the chiasmatic cavities inside the sella turcica causes deformation of the bone and compression of the hypophysis and its peduncle, often in association with neurological and endocrine symptoms. Over the past four years

The influence of age at menarche on the prevalence of disorders of the menstrual cycle among healthy university students.

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BACKGROUND Many research findings indicate long-term health risks of early age at menarche. The aim of the present study was to determine the effects of early and late onset of menarche on menstrual disturbances and anthropometric measures among university students. METHODS The research was carried

Masculinizing granulosa cell tumour.

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A 23-year-old woman had oligomenorrhea, underdevelopment of the breasts, moderate hirsutism and increased serum testosterone values associated with a benign noncystic granulosa cell tumour of the left ovary. She was frail, irritable and apathetic. Since the age of 7 she had had periodic abdominal

[Colloid cysts of the pituitary gland].

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Colloid cysts of the pituitary gland are very rare pathological lesions occurring in sellar region. Their pathogenesis is not clear. They are located between the anterior and posterior lobe of the pituitary. Colloid cysts of the pituitary gland are space occupying lesions and induce hypopituitarism,

Idiopathic hypertrophic pachymeningitis mimicking prolactinoma with recurrent vision loss.

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Idiopathic hypertrophic pachymeningitis is a rare inflammatory condition with diffuse thickening of the dura mater, which may cause a compressive effect or vascular compromise. We report on a 28-year-old Chinese woman with a history of granulomatous mastitis 7 years previously and oligomenorrhoea,

Ten-year clinical follow-up of a cohort of 51 patients with macroprolactinemia establishes it as a benign variant.

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BACKGROUND Macroprolactinemia is a common finding in patients with hyperprolactinemia. There are no published long-term follow-up studies. OBJECTIVE The aim of this study was to describe findings after prolonged follow-up in a previously published cohort of patients with

Hypeprolactinemia: still an insidious diagnosis

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Hyperprolactinemia can have different causes: physiological, pharmacological, and pathological. When investigating the etiology of hyperprolactinemia, clinicians need to be aware of several conditions leading to misdiagnosis. The most popular pitfalls are: acute physical and psychological stress,

Paraganglioma of the pituitary fossa: diagnosis and management.

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Paraganglioma of the sellar area is extremely rare with only six cases having been reported in the literature. Surgical removal of these tumors is difficult, and the transsphenoidal approach usually results in limited resection. Most authors who published reports on this tumor recommended radiation

A randomized cross-over study comparing cabergoline and quinagolide in the treatment of hyperprolactinemic patients.

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Quinagolide (QUI) and cabergoline (CAB) are dopamine agonists recently introduced for the treatment of hyperprolactinemia. In the present study, these drugs have been compared in terms of effectiveness and tolerability. Twenty patients (18 females and 2 males) with hyperprolactinemia (8 with

Unusual MRI finding of multiple adenomas in the pituitary gland: a case report and review of the literature.

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The simultaneous occurrence of multiple adenomas in the pituitary gland is a rare event. We report the coexistence of three non functioning pituitary microadenomas in a 37-year-old woman, referred to us for oligomenorrhea and headache. Biochemical evaluation revealed prolactin (131 U/liters),

CV 205-502 treatment of hyperprolactinemia.

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CV 205-502 is a nonergot oral dopamine agonist with specific D2 activity, which has a prolonged suppressive effect on serum PRL and may have fewer side-effects than other dopamine agonists. We treated 26 hyperprolactinemic women with this compound given as a single bedtime (hs) dose for up to 12

Pituitary tumors in patients with secondary amenorrhea.

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This study was undertaken to determine the prevalence of radiologically detectable pituitary tumors among patients seen initially in a gynecology clinic for a complaint of secondary amenorrhea. In a group of 144 women with secondary amenorrhea of more than 6 months' duration, 13 had radiologic

Giant prolactinoma, germline BRCA1 mutation, and depression: a case report.

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Giant prolactinomas are very rare pituitary tumors that may exhibit an aggressive behavior and present with a life-threatening condition.A 25-year-old white woman was admitted to our hospital with a headache, psychomotor retardation, reduced vision, and

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