intermittent claudication/hypoxia

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Carnosine for Peripheral Vascular Disease

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Peripheral vascular disease (PVD) has high prevalence of 10-15% in Australia and is caused by atherosclerotic occlusion of the arteries supplying the lower extremities which reduces blood flow and leads to intermittent claudication and critical limb ischaemia. No effective medication is currently

Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.

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I. SUBJECT ENROLLMENT 1. Methods of enrollment, including procedures for patient registration. Patients will be screened in the "Cardiac surgery pre-operative clinic", Massachusetts General Hospital (MGH) Cox building floor 6 (before surgery). If the patient is eligible and after obtaining the

Myocardial Injury and Postoperative Complications

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Study design The MICOLON study is a prospective, single-centre, observational cohort study on the association between 5th generation high sensitive cardiac troponin T levels and non-cardiac outcome after major abdominal surgery in patients at risk for coronary artery disease. Patient

Obstructive Sleep Apnoea in Patients With Intermittent Claudication

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In patients with peripheral artery disease (PAD), exercise induced limb ischemia (claudication) which limits walking capacity. Symptoms are due to pain at hip and/or buttock. Couple of origins may induce this pain such as vascular, cardiac, respiratory, musculoskeletal, neurologic, hematologic etc.

Risk Factors for Foot Ulceration in the Chronic Kidney Disease (CKD) Population

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The risk factors contributing to foot ulceration in the diabetic population are well published, and an abundance of these publications demonstrate the acceleration of risk factors in association with diabetic nephropathy. It is also apparent that there are risk factors present in the non-diabetic

Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease

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Purpose : Patients with end stage renal disease are at an increased risk for cardiovascular disease (CVD) and the annual mortality from CVD in end-stage renal disease (ESRD) patients is substantially higher than in the general population. Peripheral arterial disease (PAD), the most common

Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication

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This Phase 2 gene transfer study will look at whether different doses of Ad2/HIF-1α/VP16 can be tolerated safely by direct injection into the leg muscles where the blood flow is not sufficient to meet the oxygen demands of the leg muscles. The study will also assess whether patients who receive the

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