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Preliminary Testing of a Novel Device to Detect Epileptic Seizures

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Two duplicate novel medical devices conforming to safety regulation BS EN 60601 containing the unique algorithm will be evaluated in clinical trials at two hospitals over a 14 month period. Each device is time synchronised with an Electroencephalographic (EEG) videotelemetry system which is the gold

Embrace: Seizure Characterization

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Patients use the Embrace sensor with a smartphone app, "Alert". The sensor attempts to capture convulsive seizure events such as generalized tonic-clonic seizures (GTCS's), and to initiate an alert when such an event is captured. Patients can also enter seizures (captured or not, GTCS or not) into

Pediatric Seizure Movement Bed Alarm

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For parents of children with epilepsy, seizures occurring in sleep are a major concern. This frequently leads to many nights of lost sleep for parents and also to unfavorable sleeping arrangements, especially for older children and adolescents. Sudden unexplained death in epilepsy patients (SUDEP)

Neonatal Sepsis Diagnosis: ; PCR Commercial Technique and Blood Culture

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Neonatal sepsis remains one of the leading causes of morbidity and mortality both among term and preterm infants. Although advances in neonatal care have improved survival and reduced complications in preterm infants, sepsis still contributes significantly to mortality and in Neonatal Intensive Care

Study of Algorithm for Epilepsy Alert Device

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Patients undergoing Video-EEG telemetry will wear movement sensor on their wrist. The sensor will transmit continuous data to a laptop. Seizures' data (tonic or clonic) will be analyzed and transformed into an algorithm (up-graded existing preliminary algorithm). In the second phase the algorithm

Antepartum Cardiotocography With and Without Computer Analysis in High Risk Pregnancies

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Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency

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Background: The diagnosis of GH deficiency in adults is established by provocative testing of GH secretion. The insulin tolerance test (ITT) is widely regarded as the gold standard test for diagnosing adult GH deficiency despite concerns about its practicality, safety, reproducibility, and its

Advanced XLIF Monitoring Multicenter Study

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The utility of NVM5 neuromonitoring by stimulating within the surgical site during XLIF has been previously demonstrated; however, it is possible that depending on the site of injury, this method of monitoring may stimulate nerves at a location that is distal to the site of injury along the nerve

Computer-assisted Oxygen Therapy Weaning in Critically Ill Children

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Investigators will perform a feasibility study followed by a randomized, controlled study on critically ill neonatal and pediatric patients on oxygen therapy. Investigators will use a model-based adaptive control architecture to regulate FiO2 settings. A major advantage of using an "adaptive"

Cerebral Oxygenation and Burst Suppression

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Children who are routinely operated for surgery that cause high levels of circulatory changes (e.g., heart surgery) are currently routinely used to monitor the so-called regional oxygenation technique over the brain, (NIRS). Near infrared spectroscopy (NIRS) is a technique for measuring regional

Development of Potential Biomarkers for Foetal Brain Development After Congenital CMV Infection

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Rationale for the study Current tools for prediction of perinatal outcome after fetal infection with CMV are very limited. Amniocentesis is usually offered from 20 weeks gestation to diagnose fetal infection. This sampling provides an opportunity to investigate novel approaches to predicting

Quetiapine Treatment for Symptoms Associated With Borderline Personality Disorder

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Study Design: A six week, open-label, flexible dosing study using quetiapine. Subjects who qualify at Screening will then proceed to the baseline visit. If all inclusion and exclusion criteria are met, subjects will be administered quetiapine at the baseline visit. Enrollment will be 15 subjects.

Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

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Introduction Tumor treating fields (TTFields) are low-intensity (1-3 v/m) intermediate frequency (200 khz for GBM) alternating fields that disrupt cell division. The treatment is increasingly used as a supplementary modality for patients with glioblastoma (GBM). Recent randomized clinical studies

Ziprasidone for Clozapine- or Olanzapine-Associated Diabetes Mellitus

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Specific Aims: This study is a six-week, open label trial of the novel antipsychotic agent, ziprasidone, added to a stable dose of clozapine or olanzapine in 40 diabetes mellitus patients, patients with an impaired fasting glucose or insulin resistance with schizophrenia or schizoaffective

Adapting Project UPLIFT for Blacks in Georgia

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Project UPLIFT is a manualized intervention that includes a script for use by the telephone facilitators in leading activities and discussions; use of a script is possible because the delivery is not face-to-face. Activities and discussions are designed to increase knowledge about epilepsy and

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