folate/infarction

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Does Oral Pentoxifylline Administration Improve Hemoglobin in Hemodialysis Patients?

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Logáil Isteach / Cláraigh

Fifty out of 57 hemodialysis anemic patients were finally included. They were assigned to two groups of equal numbers. Oral Pentoxifylline 400mg once daily was added to the treatment group which was compared to the control group over a six months period regarding hemoglobin, hematocrit, serum

Homocysteine After Laparoscopic Roux-enY Gastric Bypass

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Logáil Isteach / Cláraigh

Homocysteine is an independent risk factor for cardiovascular disease. Changes in homocysteine levels following bariatric surgery remain controversially discussed. 708 consecutive patients underwent laparoscopic roux-en-Y gastric bypass over a 6 year period. Throughout their routine follow-up,

Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline

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Logáil Isteach / Cláraigh

INTRODUCTION Cognitive impairment, a principal cause for functional disability among the elderly, can lead to dementing illness over time mainly in the forms of Alzheimer's Disease (AD) and vascular dementia (VaD). In fact, AD prevalence is expected to rise, reaching 100 million worldwide by 2050,

Vascular and Metabolic Changes in Postmenopausal Diabetics

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Logáil Isteach / Cláraigh

Introduction Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. The presence of type 2 diabetes mellitus (T2DM) also increases the relative risk of developing cardiovascular disease in women compared to men .

Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index

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Logáil Isteach / Cláraigh

STUDY OBJECTIVES The general aim of the study is to evaluate whether wheat aleurone-rich food supplementation modifies the cardiovascular and metabolic risk profiles in subjects at increased metabolic risk. Primary objectives of the trial are to evaluate whether wheat aleurone-rich food

Chemoradiation for Bone Metastasis

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Logáil Isteach / Cláraigh

BACKGROUND Much of the clinical practice of oncology involves palliative care. In this setting ,the emphasis is on alleviation of symptoms and preservation or improvement of quality of life. A large body of clinical evidence documents the effectiveness of local-field external beam radiotherapy in

Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese Children

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Logáil Isteach / Cláraigh

Atherosclerosis is common & remains a significant clinical problem because of leading to myocardial infarction, stroke and cardiovascular death. Many studies founded hyperhomocysteinemia is an independent risk factor for those cardiovascular diseases which take responsible for about 10% of total

Cardiovascular Inflammation Reduction Trial

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Logáil Isteach / Cláraigh

While inflammation contributes crucially to atherothrombosis, it is unknown whether inhibition of inflammation per se will lower vascular event rates. The primary aim of the Cardiovascular Inflammation Reduction Trial (CIRT) is to directly test the inflammatory hypothesis of atherothrombosis by

Vascular Calcification's Risk Factors in Haemodialysis Patients

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Logáil Isteach / Cláraigh

Cardiovascular diseases (CVD) are the main causes of death and hospitalization in patients affected by ESRD . The risk of death from CVD is already detectable in the early steps of chronic renal failure and it is from 20 to 30 times higher than in the general population. In ESRD patients the

NORVIT and WENBIT - Long-term Follow-up

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Logáil Isteach / Cláraigh

The "homocysteine-hypothesis" of vascular disease has attracted considerable interest, as total plasma homocysteine levels can be easily lowered by folic acid and vitamin B12, raising the prospect that cardiovascular disease could be lowered by such B-vitamin supplementation. Two large B-vitamin

The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

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Logáil Isteach / Cláraigh

Approximately 25% of patients undergoing major surgery have known coronary artery disease (CAD) or risk factors for CAD. N2O interferes with vitamin B12 and folate metabolism. This impairs production of methionine (from homocysteine), used to form tetrahydrofolate and thymidine during DNA synthesis.

Azacitidine and Erythropoietin Versus Azacitidine Alone for Patients With Low-Risk Myelodysplastic Syndromes

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Logáil Isteach / Cláraigh

OUTLINE: This is an open label, multi-center, randomized study. Eligible patients will be randomized to one of two treatment arms: Arm A (Azacitidine + Erythropoietin) - Azacitidine Treatment 50 mg/m2 subcutaneously every other day (three times a week) for two consecutive weeks every four weeks. A

VITATOPS: A Study of VITAmins TO Prevent Stroke

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Logáil Isteach / Cláraigh

Background: Epidemiological studies suggest that raised plasma concentrations of total homocysteine (tHcy) may be a common, causal and treatable risk factor for atherothromboembolic ischemic stroke, dementia and depression. Although tHcy can be lowered effectively with small doses of folic acid,

Homocysteine Study (HOST)

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Logáil Isteach / Cláraigh

Primary Hypothesis: The primary objective of this proposal is to test the hypothesis that administration of folate, pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12) in high doses to patients with advanced chronic renal failure or end-stage renal disease and abnormally high plasma

Homocysteine and Progression of Atherosclerosis

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Logáil Isteach / Cláraigh

BACKGROUND: Few studies of progression of atherosclerotic peripheral vascular disease have been performed and none have used objective methods to evaluate disease progression in a large number of symptomatic subjects. The study is of obvious major clinical importance. Elevated plasma homocysteine is

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