cystic fibrosis/fatigue

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Prospective Surveillance of Lung Development During Childhood, Adolescence and Adulthood in Healthy and Patients With Cystic Fibrosis

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Background and project rationale: Cystic fibrosis (CF), the most common lethal inherited disease in Caucasian populations, affects approximately 1:2500 live births. It is a multisystem disorder with respiratory morbidity and mortality being the leading cause of death. Despite improved survival in

Functional Respiratory Imaging in Bronchiectasis

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Four-week prospective single centre exploratory study in adults with bronchiectasis suffering a pulmonary exacerbation. The study will endeavour to recruit ten adult subjects (male and female) who attend the Cambridge Centre for Lung Infection (CCLI) at the Royal Papworth Hospital, Cambridge, United

Prevalence and Impact of Depression and Anxiety in Cystic Fibrosis

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Numerous studies have demonstrated that patients with chronic illnesses are at increased risk for depression and anxiety. In large, well-controlled epidemiological studies, rates of depression in medical populations have ranged from 17% to 50% compared to 5% to 17.5% in healthy populations.

Simplification of CF-related Diabetes Screening at Home

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The investigators propose a pilot study to evaluate the validity and the acceptability of a home-based OGTT by comparing, in patients with CF: - Standard hospital-based OGTT with measures of plasma glucose and the use of 75g glucose beverage; - Home-based OGTT with measures of glucose using a

The Effects of Pulmonary Rehabilitation in Patients With Non-cystic Fibrosis Bronchiectasis

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METHODOLOGY Type of study - Randomised controlled trial (RCT) Study period - March 2014 to July 2016 Place of study - Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi Study group - Bronchiectasis that is not attributable to Cystic fibrosis -

Development of Diabetes in Adults With Cystic Fibrosis (CF)

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The main purpose of this study is to look at possible additional factors that might be related to the development of Cystic Fibrosis Related Diabetes (CFRD), that in itself is a unique entity and to identify an appropriate test to diagnose CFRD. There is well demonstrated evidence of delayed insulin

Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders

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BACKGROUND, SIGNIFICANCE, AND RATIONALE Failure to thrive or inadequate weight gain is a frequent complaint amongst patients seen by general pediatricians and pediatric gastroenterologists. The reasons behind this diagnosis vary widely including, but not limited to feeding disorders of diverse

Clinimetric Properties of Outcome Measures in Bronchiectasis in the UK

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Bronchiectasis is a persistent or progressive condition characterised by dilated thick-walled bronchi. The recent guidelines stipulate that high resolution computerised tomography scan (HRCT) is the radiological investigation of choice to establish the diagnosis of bronchiectasis. The key

Antioxidant Therapy in RYR1-Related Congenital Myopathy

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Although genetic disorders of muscle that present at birth are rare, RYR1-related myopathies comprise the most common non-dystrophic congenital myopathy in the United States, with a prevalence of approximately 1/90,000 people (Amburgey et al, 2011). Causative mutations in the ryanodine receptor gene

Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining

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Material abuse nowadays become a serious public health issue, among these, abusing of opioids is the most serious one. It cause HIV infection rate hiking up, recent years in Taiwan, it impairing people health as well. The successive 2 year methadone substitutive abstaining program makes HIV

Exercise Training in Patients With Non-cystic Fibrosis (CF) Bronchiectasis

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Bronchiectasis not related to cystic fibrosis (non-CF bronchiectasis) is a chronic respiratory condition characterised by permanent dilatation of the airways arising from bronchial inflammation and infection. Predominant symptoms include daily productive cough, dyspnoea and generalised fatigue. This

Dissection of Staphylococcus Aureus Infection From Colonization in Cystic Fibrosis Patients

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Protocol synopsis Title: Dissection of Staphylococcus aureus infection from colonization in cystic fibrosis patients. A non-interventional prospective, 2-year longitudinal multicenter study Study objectives: The aim of the study is to dissect S. aureus infection from colonization of the pathogen in

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