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melanoma/fatigue

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Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer

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This study will investigate immunogenomic changes with pembrolizumab alone and in combination with a selective class I histone deacetylase (HDAC) inhibitor (entinostat). The study will enroll 20 subjects with a confirmed diagnosis of MIBC (cT2-T4aN0M0) who are ineligible for (based on consensus

Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma

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Brain tumors are the first cause of cancer mortality in children and the 3rd cause in young adults. The most frequent brain tumors are gliomas and among them the most common type is astrocytoma. The most malignant astrocytoma is Glioblastoma (GBM). Standard therapy of newly diagnosed GBM patients

Quality of Life and Physical Fitness After Immune Checkpoint Inhibitors

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Participation in the study will include one study visit of approximately 2.5 hours. If possible, the study visit will be combined with a regular follow-up visit. Vena puncture is the only invasive procedure, with low risk of adverse effects. Blood will be drawn after an overnight fast. To minimize

PEMBRO With Chemo in Neo Adj Treatment of Ovarian Cancer .

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The standard procedure for initial diagnosis recommends the realization of laparoscopy first for all suspicious advanced ovarian carcinoma. This procedure should able to confirm histo-logical diagnosis and to describe the all abdominal extension of the disease. For advanced stages, complete primary

Tolerance of Targeted Therapy Used in Metastatic Melanoma in Patients Aged Over 65 and 75-year-old

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Since 2013, therapeutic care of metastatic melanoma (MM) has greatly improved, especially thanks to BRAF and MEK targeted therapies. The efficacy of these treatments that are now used daily at first line for BRAF mutated MM is widely approved. Their toxicities, in monotherapy or in association, are

Preoperative Acetaminophen and Carbohydrate Loading

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Inclusion criteria: 1. Males and females ≥ 20 years of age 2. ECOG performance status of 0-1 3. Histologically or cytologically verified non-squamous NSCLC 4. Stage IV disease, as defined by American Joint Committee on Cancer 7th edition staging, prior to first-line or second-line chemotherapy with

Interleukin-2-Induced Cognitive/Affective/Sleep Symptoms

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-Background & Significance: Alterations in cognitive, affective and sleep functioning are among the most challenging side effects experienced by 80% of patients undergoing high dose IL-2 therapy. Altered cognition includes a wide array of symptoms such as changes in concentration, attention,

Thymosin-α1 in Cancer-Related Fatigue

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Anti PD1 Antibody in Diffuse Intrinsic Pontine Glioma

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1. Diffuse intrinsic pontine glioma Diffuse intrinsic pontine glioma (DIPG) is the most lethal pediatric malignant disease. Children are usually diagnosed at the age of 6-8 years following a short history of neurological deterioration with often a combination of cranial nerve dysfunction, ataxia and

Tabectedin to Treat Children and Adolescents With Cancer

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Background: Trabectedin (ET-743) is a natural product derived from the marine tunicate Ecteinascidia turbinata. It binds to the minor groove of DNA and interacts with various transcription factors resulting in cell cycle arrest. It also inhibits transcription coupled nucleotide excision repair

Low-dose (12 Gy) TSEBT+Vorinostat Versus Low-dose TSEBT Monotherapy in Mycosis Fungoides

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Vorinostat is a histone deacetylase inhibitor (HDAC) that is FDA-approved for treatment of mycosis fungoides (MF), and has shown activity as a radiation-sensitizer in preclinical studies. Treatment of various cell lines [glioblastoma multiforme (GBM), non-small cell lung cancer (NSCLC), melanoma]

Mindfulness and Cancer Mamma - Clinical Trial MBSR Among Women Operated for Breast Cancer

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Original Research Protocol, Copenhagen January 2007 Cancer and Mindfulness: A prospective, randomized trial of a psychosocial intervention among women operated for breast cancer Background From the time of diagnosis cancer patients have a need for psychological support. Many patients handle the

Safety Study of CADI-05 in Patients With Advanced Stage Melanoma

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Because there are no highly effective treatment options for patients with advanced, unresectable melanoma, participation in clinical trials of novel therapies is frequently the best therapeutic alternative. CADI-05 is a promising agent for two reasons. First, patients with advanced melanoma

Spanish Diabetes Self-Management Program

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Diabetes self-management education is increasingly recognized in best practice guidelines and reimbursement policies as a critical ingredient of appropriate health services, especially for the Latino population. Latinos, in addition to carrying a heavy burden of diabetes and related comorbid
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