Biomarkers of Broccoli Intake: A Pilot Study
キーワード
概要
説明
Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content of glucosinolates. Breakdown products of indole glucosinolates in Brassica vegetables show promise for reducing the risk of cancer, but have received comparatively less research attention than those of aliphatic glucosinolates. The aim of this study is to investigate plasma and urinary metabolites of indole glucosinolates from broccoli and to identify novel metabolites that may have roles in reducing cancer risk.
日付
| 最終確認済み: | 10/31/2017 |
| 最初に提出された: | 09/14/2017 |
| 提出された推定登録数: | 09/17/2017 |
| 最初の投稿: | 09/18/2017 |
| 最終更新が送信されました: | 11/19/2017 |
| 最終更新日: | 11/20/2017 |
| 実際の研究開始日: | 11/05/2017 |
| 一次完了予定日: | 11/16/2017 |
| 研究完了予定日: | 11/16/2017 |
状態または病気
介入/治療
Other: Broccoli
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: Broccoli Subjects will consume a dose of broccoli on day 11 | Other: Broccoli All subjects will eat broccoli on day 11 |
適格基準
| 研究の対象となる年齢 | 21 Years に 21 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Non tobacco user - Cancer Free - Not currently taking glucosinolate/isothiocyanate containing supplements Exclusion Criteria: - Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots - Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol, or Miradon (anisindione) - History of bariatric surgery or nutrient malabsorption disease (such as celiac disease) or other metabolic disorders requiring special diet recommendations - Pregnant, lactating, or intending to become pregnant during the study period - Crohn's disease or diverticulitis - Suspected or known strictures, fistulas or physiological/mechanical GI obstruction - Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion) |
結果
主な結果の測定
1. The change in glucosinolate metabolites will be measured in blood plasma and urine. [On Day 11]
