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Biomarkers of Broccoli Intake: A Pilot Study

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USDA Beltsville Human Nutrition Research Center

キーワード

概要

The objectives of the study are 1) to characterize plasma and urinary metabolites that originate from glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin, and 4-hydroxyglucobrassicin, which are the major indole glucosinolates found in broccoli, and 2) to identify novel plasma and urinary metabolites following broccoli consumption that may have roles in reducing the risk of cancer.

説明

Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content of glucosinolates. Breakdown products of indole glucosinolates in Brassica vegetables show promise for reducing the risk of cancer, but have received comparatively less research attention than those of aliphatic glucosinolates. The aim of this study is to investigate plasma and urinary metabolites of indole glucosinolates from broccoli and to identify novel metabolites that may have roles in reducing cancer risk.

日付

最終確認済み: 10/31/2017
最初に提出された: 09/14/2017
提出された推定登録数: 09/17/2017
最初の投稿: 09/18/2017
最終更新が送信されました: 11/19/2017
最終更新日: 11/20/2017
実際の研究開始日: 11/05/2017
一次完了予定日: 11/16/2017
研究完了予定日: 11/16/2017

状態または病気

Healthy Volunteers

介入/治療

Other: Broccoli

段階

-

アームグループ

介入/治療
Experimental: Broccoli
Subjects will consume a dose of broccoli on day 11
Other: Broccoli
All subjects will eat broccoli on day 11

適格基準

研究の対象となる年齢 21 Years に 21 Years
研究に適格な性別All
健康なボランティアを受け入れるはい
基準

Inclusion Criteria:

- Non tobacco user

- Cancer Free

- Not currently taking glucosinolate/isothiocyanate containing supplements

Exclusion Criteria:

- Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots

- Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol, or Miradon (anisindione)

- History of bariatric surgery or nutrient malabsorption disease (such as celiac disease) or other metabolic disorders requiring special diet recommendations

- Pregnant, lactating, or intending to become pregnant during the study period

- Crohn's disease or diverticulitis

- Suspected or known strictures, fistulas or physiological/mechanical GI obstruction

- Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)

結果

主な結果の測定

1. The change in glucosinolate metabolites will be measured in blood plasma and urine. [On Day 11]

To track the changes of indole glucosinolate metabolites, glucosinolate metabolites will be measured in both blood plasma and urine.

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