Impact of Uterotonic Agents on Isolated Human Myometrium
キーワード
概要
説明
Postpartum hemorrhage (PPH) is a major cause of maternal mortality and morbidity. In 80% cases of PPH, the primary cause is failure of the uterus to contract after delivery of the baby, which then requires further treatment of the mother with uterotonic drugs (drugs used to contract uterus and thus prevent bleeding).
Patients participating in this study will be asked to donate a very small sample of uterine tissue during Cesarean section, which will be tested for the ability to contract after treatment with various uterotonic drugs (oxytocin, ergonovine and carboprost) in the laboratory. This information will help us know the effect of these drugs by comparing the contractile capability of the uterine tissue.
日付
| 最終確認済み: | 01/31/2014 |
| 最初に提出された: | 07/28/2009 |
| 提出された推定登録数: | 09/30/2009 |
| 最初の投稿: | 10/01/2009 |
| 最終更新が送信されました: | 02/18/2014 |
| 最終更新日: | 02/19/2014 |
| 実際の研究開始日: | 05/31/2007 |
| 一次完了予定日: | 07/31/2013 |
| 研究完了予定日: | 07/31/2013 |
状態または病気
介入/治療
Drug: Treatment
Drug: Treatment
Drug: Treatment
Drug: Treatment
Drug: Treatment
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| No Intervention: No treatment A control sample from each patient (no uterotonic drug applied) will be measured concurrently with samples treated with various drugs. | |
| Active Comparator: Treatment Samples from each patient will be bathed in solutions containing varying concentrations of either oxytocin, carboprost and ergonovine, and contractility will be measured. | Drug: Treatment Oxytocin, 10-9mol/L to 10-3mol/L, in Krebs-Henseleit solution. |
適格基準
| 研究に適格な性別 | Female |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion Criteria: - Gestational age 37-41 weeks - Non-laboring patients, not exposed to exogenous oxytocin - Patients requiring primary Cesarean section - Cesarean section under spinal anesthesia Exclusion Criteria: - Patients who require general anesthesia - Patient who had previous uterine surgery or Cesarean section - Patients with placental anomalies - Emergency Cesarean section in labor - Patients with bleeding disorders |
結果
主な結果の測定
1. Amplitude of contraction [6-8 hours]
二次的な結果の測定
1. Integrated area under response curve (AUC) [6-8 hours]
2. Basal tone [6-8 hours]
3. Frequency of contraction [6-8 hours]
