Randomly in all subjects one quadrant will be allotted as test site for placing stevia gel in the gingival sulcus having probing depth ≥ 5mm after performing thorough scaling and root planing.

Other quadrant will be allotted as a control site for placing placebo in the gingival sulcus having PD≥ 5mm after performing thorough scaling and root planing.

Periodontitis

Stevia has an anti-plaque effect because of its ability in decreasing the formation of bacterial insoluble polymers.It significantly decreases the production of TNF-R and IL-1a and slightly decreases the production of NO in stimulated cells with LPS and THP-1 showing its anti-inflammatory properties.These characteristics in combination with anti-diabetic properties could results in the effective treatment of periodontal diseases.

stevia rebaudiana bertoni

A placebo without the active drug will be placed in the control sites.

placebo

SVS Institute Of Dental Sciences

Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.

Efficacy of Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetic Patients With Periodontitis-A Split Mouth Randomized Controlled Trial.

GCF samples can be eluted from the strips by placing them in Eppendrof® tubes that contained 500 micro-litre of buffer and will be stored at -80℃ until analysis was done. The levels of GCF Ghrelin will be evaluated by using commercially available ELISA kit.

Probing depth (PD): Distance from the gingival margin to the bottom of gingival sulcus in mm.

Dr R Viswa Chandra

Principal Investigator

SVS Institute of Dental Sciences

one group of subjects receives intervention where as other group of subjects receive placebo.

Both stevia gel and placebo syringes are masked from participants and investigators.

Glucose Intolerance

Obesity

This arm will be required to consume 5 stevia drops twice daily in habitual drinks

stevia

University of Manchester

Physiological Effects of Stevia Consumption in Humans

Physiological Effects of Long-term Consumption of Non-nutritive Sweeteners in Humans: a Pilot 12 Week Randomised Trial

blood glucose levels will be measured at baseline (0) and at 15, 30, 45, 60, 90 and 120 min after the consumption of a 75 g glucose load and iAUC will be calculated

body weight will be measured on visit week 0, visit week 6 and visit week 12

participants will fill out 3 days of diet recalls before coming to all 3 study visits using Intake24

waist circumference will be measured on visit week 0, visit week 6 and visit week 12

Appetite questionnaires (three factor eating questionnaire, sweet food frequency questionnaire, Satiety, hunger, and food cravings - using the Control of Eating Questionnaire ) will be completed on visit week 0 and visit week 12

Fasting blood glucose will be measured on visit week 0 and visit week 12.

75g OGTT 2-h blood glucose will be measured on visit week 0 and visit week 12.

Total MET-minutes per week measured via the International Physical Activity Questionnaire (IPAQ).

Number of steps per day. 3 days before visit week 0, visit week 6 and visit week 12

Blood pressure will be measure on visit week 0, visit week 6 and visit week 12

Changes in gut microbiota will be measured by 16S rRNA gene sequencing. This outcome is optional and will be decided by the investigators based on the findings in the primary outcome.

This outcome is optional and will be decided by the investigators based on the findings in the primary outcome

This outcome is optional and will be decided by the investigators based on the findings in the primary outcome.

Nikoleta Stamataki

PhD student

Lancaster University

2-group parallel 12-week intervention study with control group

Participants will be asked to consume 180 mg/day of sucralose (in the form of capsules which is equivalent to three 12-oz cans of diet soda) for 14 days. According to the FDA, a 150 lb. person may consume up to 340 mg/day of sucralose (or 5.5 12-oz cans of sucralose-sweetened diet soda).

Participants will be asked to consume 180 mg/day of stevia (in the form of capsules which is equivalent to three 12-oz cans of diet soda) for 14 days. According to the FDA, a 150 lb. person may consume up to 800 mg/day of stevia (or about 12 cans of stevia-sweetened diet soda).

Impaired Glucose Tolerance

Sucralose

Stevia

ECRC

Sucralose, Stevia, Gut Microbiome and Glucose Metabolism

An oral glucose tolerance test will be administered before and after consuming assigned sweetener to determine change in 2-hour glucose

Gut microbiota will be measured before and after consuming assigned sweetener to determine change in gut microbiota.

Individual data will not be made available.

University of Minnesota

Food or beverages containing Aspartame in comparison to Stevia or Sucrose

Food or beverages containing Sucrose in comparison to Aspartame or Stevia

Food or beverages containing Stevia in comparison to Aspartame or Sucrose

Type 2 Diabetes

The morning breakfast after a 12-h fast and consumed a standard 469 kcal breakfast consisting of cereal, milk, toast with butter, and orange juice. Tea and crackers with cream cheese sweetened with stevia Whole Foods 365 Brand, aspartame equal sweetener, or sucrose participants consumed this preload 20 min before their test lunch and dinner meals. The Test lunch meal consisted of sandwiches, potato chips, and cookies, and the test dinner meal was a self-selected buffet-type meal (I.e., Macronutrient Self-Selection Paradigm) Geiselman et al,. 1998)

Aspartame

Sucrose

Pennington Biomedical Research Center

Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults

Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults: A Pilot Study

Test whether preloads of tea and crackers with cream cheese sweetened with Stevia lover postprandial insulin levels compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by measuring blood insulin and glucose levels immediately prior to the lunch preload,immediately before lunch test meal, and at thirty minutes, one hour, and two hours after the lunch test meal.

Test whether preloads of tea and crackers with cream cheese sweetened with Stevia have different hedonic ratings compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by examining hunger and satiety ratings after the preload.

Test whether preloads of tea and crackers with cream cheese sweetened with stevia have different satiating effects compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by examining food consumption 20 minutes and after lunch and dinner preloads, as well as total food consumption.

stevia eupatoria/saldiklis

Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.

Physiological Effects of Stevia Consumption in Humans

Sucralose, Stevia, Gut Microbiome and Glucose Metabolism

Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults

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