Cannabis

Dependence

Rimonobant

Rimonabant

University of Maryland, Baltimore

National Institute on Drug Abuse, Biomedical Research Center (BRC)

Antagonist-Elicited Cannabis Withdrawal

National Institute on Drug Abuse (NIDA)

Participants in this condition will receive empathic exploration of their thoughts regarding marijuana use, provision of information on possible consequences of marijuana use during pregnancy and potential benefits of changing use (with permission), normed feedback, use of Motivational Interviewing techniques to elicit their own reasons for change, video testimonials modeling successful change, and information on change methods with optional goal setting.

Participants in this condition will chose the frequency and time of text messages that will continue until childbirth or the participant opts out. The text messages will be a mix of marijuana targeted content (without directly referring to marijuana in a way that implies use by the participant) and general content related to healthy pregnancy; using appropriate humor and tips for community resources. Tailoring will focus on gestational age, self-efficacy, and social support.

Participants in this arm will receive both the computerized intervention and tailored text messaging intervention as described in the eSBIRT and Tailored texting arms.

Participants in the arm will participant in screening and the baseline assessment conducted on the computer only. They will not receive an intervention.

Participants in this arm of the study will only answer the screening questions and will not be asked the baseline assessment or participate in an intervention.

Participants in this condition will receive empathic exploration of their thoughts regarding marijuana use, provision of information on possible consequences of marijuana use during pregnancy and potential benefits of changing use (with permission), normed feedback, use of Motivational Interviewing techniques to elicit their own reasons for change, video testimonials modeling successful change, and information on change methods with optional goal setting.
eSBIRT: A single 20 minute interactive computer-delivered intervention designed to promote motivation to change prenatal marijuana use, without presuming the participant to be currently using marijuana while pregnant.

Electronic SBIRT (eSBIRT)

Participants in this condition will chose the frequency and time of text messages that will continue until childbirth or the participant opts out. The text messages will be a mix of marijuana targeted content (without directly referring to marijuana in a way that implies use by the participant) and general content related to healthy pregnancy; using appropriate humor and tips for community resources. Tailoring will focus on gestational age, self-efficacy, and social support.
Tailored texting: Group text messaging software from Trumpia, Inc. will be used to create the tailored text messages that will be sent to participants assigned to this intervention. Text messages will sent after the initial study participation visit until childbirth or participant opts out of receiving them.

Tailored Texting

Participants in this arm will receive both the computerized intervention and tailored text messaging intervention as described in the eSBIRT and Tailored texting arms.
eSBIRT: A single 20 minute interactive computer-delivered intervention designed to promote motivation to change prenatal marijuana use, without presuming the participant to be currently using marijuana while pregnant.
Tailored texting: Group text messaging software from Trumpia, Inc. will be used to create the tailored text messages that will be sent to participants assigned to this intervention. Text messages will sent after the initial study participation visit until childbirth or participant opts out of receiving them.

eSBIRT & Texting

Assessment Only

Screening Only

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

The Alcohol Smoking and Substance Involvement Screening Test (ASSIST) was developed by the World Health Organization (WHO) and is used to detect and manage substance use and related problems. For this measure the sum of all the marijuana related items was calculated for each participant. We reported the median score for each intervention arm group. Scores on the marijuana subscale range from 0 to 33. Scores of 0 to 3 present low risk; 4 - 26 moderate risk (at risk of health & other problems from current pattern of use); and 27 - 33 high risk (severe problems & likely to be dependent).

ASSIST marijuana score

Marijuana use will be measured at the time of delivery of their infant by self-report (TimeLine Follow Back interview - TLFB) and urine analysis. This will represent the number of participants who abstinent (reported no marijuana use and had a negative toxicology urine screen) from marijuana for the 7 days prior to delivery.

Number of Participants Abstinent From Marijuana for the 7 Days Prior to Delivery

Marijuana use will be measured at the time of delivery of their infant by self-report (TimeLine Follow Back interview - TLFB) and hair toxicology analysis. This will represent the number of participants who were abstinent (reported no marijuana use and had a negative hair toxicology results) from marijuana for the 90 days prior to delivery.

Number of Participants Abstinent From Marijuana for the 90 Days Prior to Delivery

Overall Study

Dr. Jessica Beatty

Marijuana Use

Pregnancy

A single 20 minute interactive computer-delivered intervention designed to promote motivation to change prenatal marijuana use, without presuming the participant to be currently using marijuana while pregnant.

eSBIRT

Group text messaging software from Trumpia, Inc. will be used to create the tailored text messages that will be sent to participants assigned to this intervention. Text messages will sent after the initial study participation visit until childbirth or participant opts out of receiving them.

Tailored texting

Wayne State University

Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy

Computer-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) for Marijuana Use in Pregnancy: Planning a Stage II Trial

Steven J. Ondersma

Professor

National Institutes of Health (NIH)

Cannabis Use

Neurocognitive Dysfunction

Genetic Predisposition

Venous blood will be obtained for later genome analysis

Genome analysis

Queen Mary Hospital

Prospective Evaluation on Cognitive Function and Its Associated Genetic Vulnerability in Cannabis Users

Substance Misuse To Psychiatric Disorders for Cannabis—Prospective Evaluation on Cognitive Function and Its Associated Genetic Vulnerability in Cannabis Users (SToP-C—PeCoG)

Subject assessed with a maximum score of 30. Those who score 26 or below will consider to have mild cognitive impairment

Subject who scores 12 or below will be considered having frontal dysexcutive function

Subject will be assessed with the scale for their immediate, delayed, visual and auditory memory

venous blood test will be done on consented subject for genome analysis for associated single nucleotide polymorphisms on 4 related chromosomes identified from literature associated with cannabis use disorder and neurocognitive impairment

african/mbangi

Antagonist-Elicited Cannabis Withdrawal

Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy

Prospective Evaluation on Cognitive Function and Its Associated Genetic Vulnerability in Cannabis Users

Hifadhidata kamili ya mimea ya dawa inayoungwa mkono na sayansi