Diagnosis of ascites in infants and children by history, examination and investigations

Ascites

Diagnosis of Ascites in Infants and Children

Diagnosis of ascites in infants and children fromega age of 1month to 18 year

Asmaa abo bakr Ahmed

Doctor

Assiut University

Ovarian Cancer

Endometrial Cancer

This trial is limited to female participants, as it is a study of ovarian and endometrial cancer patients.

Participants in the usual care plus ketogenic diet group will receive usual care plus dietary counseling in accordance with a ketogenic diet such that ~5% energy comes from carbohydrate, 25% energy from protein, and 70% energy from fat for the duration of the 12 week study.

Ketogenic diet

Participants in the usual care plus AND diet group will receive usual care plus dietary counseling in accordance with the Academy of Nutrition and Dietetics guidelines in 2013 for the duration of the 12 week study.

AND diet

Targeted Disruption to Cancer Metabolism and Growth Through Dietary Macronutrient Modification

Targeted Disruption to Cancer Metabolism Through Dietary Macronutrient Modification

fasting serum concentrations of a variety of inflammatory markers

Physical and mental health functioning as assessed by the Medical outcomes Study Short Form-12 Health Survey, which produces a physical component summary and mental component summary score.

Perceived hunger assessed by a visual analog scale

Cravings for particular types foods (fats, sweets, starches) as assessed by the Food Craving Inventory

fasting serum concentrations of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides

Barbara Gower

Professor

University of Alabama at Birmingham

American Institute for Cancer Research

This study is a randomized clinical trial with a parallel arm design to evaluate the effects of 12 weeks of usual care plus AND or usual care plus KD on women with ovarian and endometrial cancer.

Normal lifestyle. Subjects will undergo a muscle and fat biopsy at the start of the 4 w period and after. An oral glucose test at the start and after completion of the 4 week period. Physical activity and glucose will be monitored during the study period.

Followed by a 1 week normal run in period subjects will undergo a 3 min bout, every half hour between 8 am and 6 pm comprises of simple low-intensity exercise such as moderate walking about or climbing a flight of stairs over a 3-week period. Subjects will undergo a muscle and fat biopsy at the start of the 4 w period and after. An oral glucose test at the start and after completion of the 4 week period. Physical activity and glucose will be monitored during the study period.

Obesity

Insulin Resistance

Sedentary Lifestyle

Normal lifestyle

Exercise

muscle and fat biopsy

Glucose concentrations during the study period

Continuous glucose monitoring

Objective measurements of standing and sitting time

Activity monitoring (ActivePal)

Danderyd Hospital

Frequent Activity Snacks Breaks

Frequent Activity Snacks Breaks - Interrupting Sedentary Behaviour

Oral glucose tolerance test including baseline glucose and insulin

insulin signalling cascade, the pathways that regulate protein synthesis and atrophy, as well as the content and function of mitochondria

The pathways that regulate protein synthesis and atrophy

Objective measures of standing and sitting

Erik Näslund

Karolinska Institutet

Baker IDI Heart and Diabetes Institute

Australian Catholic University

Stockholm County Council, Sweden

PCOS

Furocyst

Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects

Dept of Obs & Gynae, King George's Medical University, Lucknow, UP, India

Furocyst - Poly Cystic Ovary Syndrome Study

To Study the Efficacy and Safety of Furocyst in Poly Cystic Ovary Syndrome Patients (PCOS)

Chemical Resources

High-Risk Cancer

Fenretinide

Placebo

European Institute of Oncology

Fenretinide in Healthy Young Women at Genetic and Familial Risk

Breast Cancer Prevention With Fenretinide in Young Women at Genetic and Familil Risk. A Phase III Randomized Clinical Trial

The aim of the proposed trial is to assess the efficacy of fenretinide, (4 hydroxyphenilretinamide, 4-HPR), a vitamin A derivative, in reducing the incidence of breast cancer (BC) in healthy young premenopausal women at increased familial/genetic risk for BC (i.e. BRCA1 or BRCA2 mutation carriers or subjects at high risk of being carriers). The primary endpoint is the incidence of invasive BC and ductal intraepithelial neoplasia (DIN), histologically diagnosed.

Incidence of other non-invasive breast disorders, ovarian cancers and other cancers.
Early intermediate biomarkers of efficacy after 12, 36, and 60 months of treatment. We will also evaluate the percent change in circulating biomarkers of the IGF system, androgens, retinol binding protein (RBP-4), insulin, blood glucose and VEGF, after 12, 36 and 60 months of treatment.

ovarian neoplasms/triglyceride

Diagnosis of Ascites in Infants and Children

Targeted Disruption to Cancer Metabolism and Growth Through Dietary Macronutrient Modification

Frequent Activity Snacks Breaks

Furocyst - Poly Cystic Ovary Syndrome Study

Fenretinide in Healthy Young Women at Genetic and Familial Risk

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