For each subject, one tear trough will be injected with hyaluronic acid filler mixed with saline. This arm will act as a control to evaluate the efficacy of PRF with hyaluronic acid.

For each subject, one tear trough will be injected with hyaluronic acid filler mixed with Platelet Rich Fibrin (PRF). This study seeks to determine the efficacy of PRF in volumization of the tear trough and improvement of skin quality. This is the experimental condition.

Tear Trough Hollowing, Under Eye Bags

The use of Restylane-L to volumize the tear trough has been well documented. Combining Restylane-L with Platelet Rich Fibrin (PRF) will be studied to evaluate if PRF enhances the volumization and skin quality of the treated areas.

Hyaluronic Acid Filler and Platelet Rich Fibrin (PRF)

This intervention will use saline as a control to compare with PRF when mixed with hyaluronic acid fillers. Saline will dilute the HA filler in the same way PRF will, however saline as no growth factors or properties that will enhance treatment.

Hyaluronic Acid Filler and Saline

Rejuva Medical Aesthetics

Platelet Rich Fibrin for Tear Trough Rejuvenation

Platelet Rich Fibrin (PRF) With Hyaluronic Acid Fillers for Tear Trough Rejuvenation

Restoration of volume loss and improved skin quality of the tear troughs

Reduction in wrinkles and appearance of "crepey" skin.

The data will be collected, organized, and summarized in a manuscript to be submitted for publication. The publication will be available for other researchers to review.

Alex Reivitis

Clinical Research Coordinator

10 subjects will receive treatment with hyaluronic acid fillers for tear trough rejuvenation. Each subject with have one tear trough treated with HA filler mixed with Platelet Rich Fibrin, and the other tear trough injected with HA filler mixed with saline. The subject with be blind as to which tear trough contains the PRF. This will be randomly assigned for each subject and documented by the CRC.

The subject will not be aware of which tear trough has the PRF condition. Additionally, the blind observer, who is going to evaluate improvement based on before/after photos, will also be blind to to which tear trough as treated with the PRF condition.

The first group will use the two techniques under study combined: Infrared Laser + Amber LED (830 nm - 150mW + 590 nm - 1.500 mW)

The second group will use only Amber LED (590 nm - 1.500 mW)

Aging

Wrinkles

This group will make the application on the machine program that uses laser and led together to photorejuvenation . Laser is applied for 30 seconds and soon after begins the LED by 2:30 minutes in each region to apply.

Infrared Laser + Amber LED

This group will make the application on the machine program that uses LED photorejuvenation only 3 minutes of time for each area to be applied.

Amber LED

Effects of Application LED Therapy and Laser Therapy in Facial Rejuvenation

Effects of Application LED Therapy and Laser Therapy in Facial Rejuvenation: Pilot Study

Patricia Viana da Rosa

Adjunct Professor

Federal University of Health Science of Porto Alegre

Moderate intensity treadmill exercise three times per week for 10-12 weeks

Serve as a sedentary (little exercise) control for 10-12 weeks

Autophagy and Apoptosis in Human Satellite Cells

Participants will undergo supervised exercise 3 times a week for 10-12 weeks.

Exercise

Participants will be asked to maintain the sedentary lifestyle that they already have for 10-12 weeks.

Sedentary

Duke University Medical Center

Rejuvenation of Aged Muscle Stem Cells Through Exercise

Muscle stem cell function will be compared across age groups at baseline, post-acute (1 week after baseline), and post-chronic (12 weeks after baseline) using a One Way ANOVA or t test for specific comparisons

Duke University

National Institutes of Health (NIH)

National Institute on Aging (NIA)

Active and Placebo. Participants received retinol lotion on one arm and placebo to match on the other arm.

Participants in the group will give tissue sample only for comparison.

Participants received retinol lotion on one arm and placebo to match on the other arm.

Older Group Ages 55-75

Participants in the group will give a tissue sample from one arm only for comparison.

Young Group Ages 18-25

Total

Sex: Female, Male

Race (NIH/OMB)

Region of Enrollment

Differences in transcript levels are reported as the number that were upregulated or downregulated in the participant's retinol-treated arm versus their placebo-treated arm.

Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo)

Transepidermal Water Loss of arm skin was measured in units of grams/hours/meters squared.

Participants in the older group (ages 55-75), retinol arm.

Retinol Treated Arm

Participants in the older group (ages 55-75), placebo arm.

Placebo Treated Arm

Transepidermal Water Loss

Wrinkling was assessed by the investigator using a 10-point Likert scale (range 0 to 9, lower scores correspond to less wrinkling).

Severity of Arm Skin Wrinkling

Elasticity was assessed using cutometry (R2 curve) as millimeters per second

Elasticity on Arm Skin

Skin and subcutaneous adverse events were assessed for this outcome and documented and scored according to CTCAE version 4.03.

Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events

Differences in transcript levels are reported as the number of genes that were upregulated or downregulated in the Younger Group participant tissue samples, as compared to a baseline provided by tissue samples collected from the Older Group (prior to their treatment).

Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline)

Overall Study

Dr. Anne L. Chang

Intrinsic Aging of Skin

Retinol

Placebo

Stanford Dermatology

Retinol on Human Skin Aging in East Asian Descent

Discovery of Effects of Retinol on Human Skin Aging in Individuals of East Asian Descent

Anne Chang

Associate Professor of Dermatology

Stanford University

Nicotinamide riboside (NR) and pterostilbene oral capsules 250mg/50mg (Step 1) twice daily for 2 days. If the study progresses to Steps 2, 3, and 4, then 2x, 3x, and 4x the doses in Step 1 will be administered.

Capsules identical in appearance and number to the agent used in Steps 1-4.

Acute Kidney Injury

NR is a form of vitamin B3; Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries

Basis

Massachusetts General Hospital

Pharmacokinetics, Pharmacodynamics and Safety of Basis in Acute Kidney Injury Study

Randomized, Double-blind, Placebo-controlled, Stepwise Study of the Pharmacokinetics, Pharmacodynamics & Safety of Escalating Doses of Basis (Nicotinamide Riboside and Pterostilbene) in Patients With Acute Kidney Injury (AKI)

Maximum plasma concentration [Cmax] of NR after oral administration of Basis

Maximum plasma concentration [Cmax] of pterostilbene after oral administration of Basis

Area Under the Curve [AUC] of NR after oral administration of Basis

Area Under the Curve [AUC] of pterostilbene after oral administration of Basis

Subjects will be interviewed to determine onset of nausea, abdominal pain, vomiting, diarrhea, or rash. Adverse events will be characterized as probably related, probably not related, or unknown

comprehensive metabolic panel (including liver function tests), complete blood count

To determine the increase in NAD+ levels in white blood cells (WBCs) following twice daily Basis administration

Dose of Basis that leads to 50% increase in NAD+ levels in WBC

Dose of Basis that leads to 100% increase in NAD+ levels in WBC

Eugene Rhee

Assistant Professor of Medicine

Elysium Health

Randomized 5 subjects in active arm (Basis) : 1 subject in control (placebo)

Placebo capsules are identical in appearance to active agent.

Participants in placebo group will receive Placebo Oral Tablets identical to the metformin tablets for 10 months.

Participants in placebo group will receive an escalating dose of Metformin hydrochloride tablets up to a dose of 2500mg for 10 months.

Insulin Resistance

Obesity

Obesity, Abdominal

Metformin treatment of 2500mg for 10 months in the Metformin group

Metformin Hydrochloride

Placebo treatment of identical tablets to metformin group

Placebo Oral Tablet

Mayo Clinic in Rochester

Metformin Effect on Brain Function in Insulin Resistant Elderly People

Multivoxel chemical shift imaging (dual-tuned proton (Helmholtz pair)/phosphorus (loop) flex coil will be applied such that the phosphorus loop overlies the right DLPFC, WIP 1071, axial 1.5 cm slice prescribed to encompass the right dorsolateral prefrontal cortex, 12x12 matrix reconstructed to 16x16 matrix, 1.5 cm nominal isotropic voxels, TR=1500) will be used to acquire phosphorus metabolite information from the right DLPFC

An axial 2D symmetric multi-slice (SMS) diffusion tensor imaging (DTI) sequence with 60 diffusion directions, 5 B0 acquisitions and 2mm isotropic voxels (TR=3000, TE=73, FA=90, ETL 43, both A-P and P-A phase encoding for B0 images) will be used to acquire white matter integrity data related to metformin.

Oxygen flux in isolated muscle mitochondria will be measured using a titrated substrate protocol on an Oroboros oximetry instrument.

To measure global brain blood flow information: An axial 3D pseudo-continuous arterial spin labelling (pCASL) sequence (WIP 818) with 4mm isotropic voxels (TI1=1800, TI2=3600, iPat ≤ 2) will be used to acquire quantitative blood flow measurements (flow in ml/100g/min) throughout the brain.

K. Sreekumaran Nair

Professor of Medicine and Consultant in Endocrinology and Metabolism

Mayo Clinic

Study will be a double-blind, placebo-controlled, randomized design.

Gout

The purpose of this study is to investigate the effect of uric acid-lowering drugs on sperm quality, so the inclusion of patients must be male.

The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients：A Prospective Cohort Study

According to the current world health orgnization semen analysis guidelines, semen quality evaluation can not use a single index to evaluate semen quality grade. The change of semen quality needs to be evaluated comprehensively from three aspects, namely basic semen analysis, sperm DNA integrity analysis, and sperm damage via oxidative stress. Therefore, all the measurements will be aggregated to arrive at the reported value as semen quality.

The level of serum uric acid in micro-friction per liter during the treatment of reducing uric acid were recorded in the case report form.

white/抗衰老