veratrine/hypoxia

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F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery.

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OBJECTIVE The persistent sodium current is involved in myocardial ischaemia and is selectively inhibited by the newly described 3-(R)-[3-(2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate (F 15845). Here, we describe the pharmacological profile of F 15845

Transient hypoxia alters striatal catecholamine metabolism in immature brain: an in vivo microdialysis study.

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Microdialysis probes were inserted bilaterally into the striatum of 7-day-old rat pups (n = 30) to examine extracellular fluid levels of dopamine, its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). The

Increase in chloride-dependent L-glutamate transport activity in synaptic membrane after in vitro ischemic treatment.

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The effect of energy failure on Cl(-)-dependent L-glutamate (L-Glu) transport was examined with an in vitro preparation. Rat brain slices were incubated in low oxygen and glucose-deprived medium (in vitro ischemia), and a synaptic membrane fraction was prepared from the slices. Cl(-)-dependent

Pathophysiology of cardiomyocytes.

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Isolated cardiomyocytes lend themselves very well to the quantification of pathological damage and to the determination of reversible versus irreversible changes. These single cells were used to study the cellular response to a variety of pathologic stimuli that impair structure and function.

Electrical phenomena in nerve; crab nerve.

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The resting and action potentials of the leg nerves of the spider crab are reduced by procaine, cocaine, iodoacetate, KCl, and veratrine. The first three agents depress the sensitivity of the resting potential to anoxia, while the last can be shown to augment it. Glucose sustains activity and the

Potassium movement in relation to nerve activity.

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The depolarization of crab nerve during repetitive stimulation is unaffected by the presence of glucose or by an increase in the calcium content of the medium. It is increased in both amplitude and rate by veratrine; in the presence of this alkaloid mixture the rate but not the magnitude of the

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