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Página 1 desde 42 resultados
Age-related Macular Degeneration: Detection of Onset of New Choroidal Neovascularization (AMD DOC Study)
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Primary Objective:
The purpose of this study is to determine the sensitivity of the OCT in detecting conversion to neovascular AMD by two years in eyes at high risk for CNV, with FA serving as the gold standard.
Secondary Objectives:
- To determine the specificity, positive predictive value, and
Near-Focus NBI Classification of Villous Atrophy in Suspected Coeliac Disease: International Development and Validation
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Coeliac disease (CD) is an autoimmune condition by the exposure to gluten in patients who are genetically susceptible. The global prevalence is thought to be 1%, and incidence rate of CD in the UK is approximately 13.8 per 100,000 person-years with greater than fourfold increase in incidence over
Metabolomics: A Novel Tool for Investigating the Pathogenesis of Age-related Macular Degeneration
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Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and the third cause of global blindness. It is an eye-ageing disease with tremendous impact in daily quality of life. Clinically, AMD is a progressive disease, which evolves from early to late
Clinical Outcome of Aortic Dissection
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Aortic dissection refers to the blood in the aortic lumen entering the aortic mediastinum from the tear of the aortic intima, separating the mediastinum and extending along the long axis of the aorta to form the true and false separation state of the aortic wall. Risk factors for aortic dissection
Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study
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Problem: Chronic steroid use causes a wide range of side effects, of which bone disease and adrenal suppression cause significant morbidity. Bone disease, which includes osteopenia, fractures, and osteonecrosis, is very common. In patients on chronic steroids, fractures can occur in up to 30-50%,
Robot-Assisted MRI-Guided Prostate Biopsy
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While prostate cancer is the most common non-dermatologic malignancy among men in the US, it is frequently indolent and may not require radical therapy, i.e. radical prostatectomy or external beam radiotherapy. There has been increased interest in conservative approaches to low risk disease,
Carbohydrate Estimation Supported by the GoCARB System
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Background
For individuals with type 1 diabetes (T1D) the current gold standard to evaluate the carbohydrate (CHO) amount of a meal is by carefully weighing its different components and calculating the CHO content using reference nutritional tables. The resulting CHO amount is then used to define
Assessment of the Predictive Value of the Acetic Acid Test in Surgery Condition for the Detection of Dysplastic Lesions in Patients With Anal Condylomatosis
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Kidney Biomarkers of Acute Kidney Injury in Patients With Knee Arthroplasty
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Acute renal deterioration is a serious adverse event in elective surgery. Serum creatinine based diagnostics of acute kidney injury may delay diagnosis and produce false negative results since serum creatinine is affected by diet, muscle mass, used hydration therapy. In recent times new markers have
Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study
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The first aim of the current project is to test the precision of AFI in the epidermis of 10 healthy volunteers. For this purpose, a range of nociceptive electrical stimuli with increasing intensities (5Hz @ 0.5mA-1.0mA) and one innocuous control stimulus (2000Hz @1mA) will be delivered to the third
Dragon Study Europe
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Aortic dissection (AD) is the surging of blood through a tear in the aortic intima with separation of the intima and media and creation of a false lumen.
The dissection may occur anywhere along the aorta and extend proximally or distally into other arteries. It occurs most commonly at the proximal
INTERCOMEX Donor-Derived Cell Free DNA Study
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There is a need for better screening of kidney transplant patients for rejection. Patients with kidney transplants are routinely tested (creatinine, urine protein, histology and donor specific antibody (DSA) as standard of care to detect rejection, but these tests are not adequate. Rejection is
SudoScan as a Biomarker of Parkinson's Disease
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Trial of a Best-Practice Alert in the Electronic Medical Record to Reduce Unnecessary Telemetry Monitoring
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Physicians often order continuous cardiac monitoring (telemetry) for their patients in the hospital. Telemetry provides real-time heart rate and rhythm monitoring and can be useful for detecting arrhythmias and evaluating the response to cardiac therapies. Leads on the patient's chest detect the
Assessment Study of Steroid Effect in Relapsing Multiple Sclerosis Subjects Treated With Glatiramer Acetate
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One interim analysis was planned for possible early termination due to proven efficacy when 75% of the preplanned 500 (approx. 375 patients) recruited patients completed the entire study duration or early discontinued.
In addition to the stopping rule already given for proven efficacy, the sponsor
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